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GLP-1 medications slow gastric emptying and affect appetite-regulating hormones, which can trigger nausea as a side effect

This approach has been designed to determine the maximum suggested starting dose, even though lower starting doses may also be suitable in some first-in-human clinical trials

It upregulates the expression of Pink1, Parkin, Bnip3 and BCL2 like 13 (Bcl2l13) proteins and LC3B-II/I ratio, promotes mitophagy in the skeletal muscle of mdx52 mice, and significantly inhibits the expression of inflammatory and OS marker proteins (CD68, CD206, SOD1, and SOD2), which in turn improve the anti-fatigue ability of skeletal muscle of mdx52 mice

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